Search on: INTERFERING RNA, SHORT 
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Descriptor English:   RNA, Small Interfering 
Descriptor Spanish:   ARN Interferente Pequeño 
Descriptor Portuguese:   RNA Interferente Pequeno 
Synonyms English:   Short Hairpin RNA
Short Interfering RNA
Small Hairpin RNA
Small Interfering RNA
piRNA
scnRNA
shRNA
tasiRNA
Hairpin RNA, Short
Hairpin RNA, Small
Interfering RNA, Short
Interfering RNA, Small
Piwi Interacting RNA
RNA, Piwi Interacting
RNA, Short Hairpin
RNA, Short Interfering
RNA, Small Hairpin
RNA, Small Scan
Repeat Associated siRNA
Scan RNA, Small
Trans Acting siRNA
siRNA, Repeat Associated
siRNA, Trans Acting
Piwi-Interacting RNA
Repeat-Associated siRNA
RNA, Piwi-Interacting
RNA, Scan
Scan RNA
siRNA
siRNA, Repeat-Associated
siRNA, Trans-Acting
Small Scan RNA
Trans-Acting siRNA  
Tree Number:   D13.150.650.700
D13.444.735.150.700
D13.444.735.790.552.875
Definition English:   Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions. 
Indexing Annotation English:   Do not confuse with defective interfering RNA (diRNA), a viral RNA of DEFECTIVE VIRUSES.
See Related English:   MicroRNAs
RNA Interference
RNA-Induced Silencing Complex
 
History Note English:   2003; use RNA, SMALL INTERFERING (NM) 2001-2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   37536 
Unique Identifier:   D034741 

Occurrence in VHL:
 

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